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Effects of 5-iminodaunorubicin on nucleoli of rats.

作者信息

Peters J H, Evans M J, Jensen R A, Acton E M

出版信息

Cancer Chemother Pharmacol. 1980;4(4):263-6. doi: 10.1007/BF00255271.

DOI:10.1007/BF00255271
PMID:7438328
Abstract

We have confirmed that doxorubicin induces irreversible changes in the nucleolar ultrastructure of myocardial cells of rats. Similar changes were not caused by an equal dose of the synthetic analogue, 5-iminodaunomycin. These results combined with previous and current comparative tests with this analogue, doxorubicin, and daunomycin suggest that 5-iminodaunomycin may serve as a less cardiotoxic anthracycline derivative.

摘要

相似文献

1
Effects of 5-iminodaunorubicin on nucleoli of rats.
Cancer Chemother Pharmacol. 1980;4(4):263-6. doi: 10.1007/BF00255271.
2
Effects of adriamycin on ultrastructure of nucleoli in the heart and liver cells of the rat.阿霉素对大鼠心脏和肝脏细胞中核仁超微结构的影响。
Cancer Res. 1976 May;36(5):1580-4.
3
Acute ultrastructural effects of the antitumor antibiotic carminomycin on nucleoli of rat tissues.抗肿瘤抗生素洋红霉素对大鼠组织核仁的急性超微结构效应
Cancer Res. 1979 Apr;39(4):1239-44.
4
Comparison of adriamycin-induced nucleolar segregation in skeletal muscle, cardiac muscle, and liver cells.阿霉素诱导的骨骼肌、心肌和肝细胞中核仁分离的比较。
Cancer Treat Rep. 1978 May;62(5):771-8.
5
Electrocardiographic and transmembrane potential effects of 5-iminodaunorubicin in the rat.5-亚氨基柔红霉素对大鼠心电图及跨膜电位的影响。
Cancer Res. 1984 Sep;44(9):4030-9.
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5-Iminodaunorubicin. Reduced cardiotoxic properties in an antitumor anthracycline.5-亚氨基柔红霉素。一种抗肿瘤蒽环类药物，其心脏毒性有所降低。
J Med Chem. 1979 Jan;22(1):36-9. doi: 10.1021/jm00187a009.
7
Anthracycline-induced cardiomyopathy is manifested in decreased protein synthesis, impaired intracellular regeneration, and non-necrotic death of cardiomyocytes.蒽环类药物引起的心肌病表现为蛋白质合成减少、细胞内再生受损以及心肌细胞的非坏死性死亡。
Bull Exp Biol Med. 2001 May;131(5):505-10. doi: 10.1023/a:1017956922385.
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Further studies on satellite nucleoli in rat and mouse hepatocytes.大鼠和小鼠肝细胞中卫星核仁的进一步研究。
Exp Cell Res. 1984 Mar;151(1):80-6. doi: 10.1016/0014-4827(84)90357-4.
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Transcriptional activity and ultrastructure of morphologically different types of nucleoli isolated from hepatocytes of normal and hepatectomized rats.从正常和肝切除大鼠肝细胞中分离出的形态不同类型核仁的转录活性和超微结构
Epithelial Cell Biol. 1994;3(2):54-60.
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Selective mitochondrial alterations induced by a single dose of daunorubicin or 4-demethoxydaunorubicin in mouse ventricular myocardium.单次剂量柔红霉素或4-去甲氧柔红霉素诱导的小鼠心室心肌选择性线粒体改变。
Tumori. 1980 Feb;66(1):27-34. doi: 10.1177/030089168006600103.

引用本文的文献

1
Comparative cytotoxicities of various morpholinyl anthracyclines.多种吗啉基蒽环类药物的细胞毒性比较
Cancer Chemother Pharmacol. 1985;14(2):160-4. doi: 10.1007/BF00434357.

本文引用的文献

1
Adriamycin. A new anticancer drug with significant clinical activity.阿霉素。一种具有显著临床活性的新型抗癌药物。
Ann Intern Med. 1974 Feb;80(2):249-59. doi: 10.7326/0003-4819-80-2-249.
2
Effects of adriamycin on ultrastructure of nucleoli in the heart and liver cells of the rat.阿霉素对大鼠心脏和肝脏细胞中核仁超微结构的影响。
Cancer Res. 1976 May;36(5):1580-4.
3
Adriamycin-a review.阿霉素综述
J Natl Cancer Inst. 1975 Dec;55(6):1265-74. doi: 10.1093/jnci/55.6.1265.
4
Myocardial injury induced by a single dose of adriamycin: an electron microscopic study.单次剂量阿霉素诱导的心肌损伤：一项电子显微镜研究
Tumori. 1976 Sep-Oct;62(5):517-28. doi: 10.1177/030089167606200506.
5
5-Iminodaunorubicin. Reduced cardiotoxic properties in an antitumor anthracycline.5-亚氨基柔红霉素。一种抗肿瘤蒽环类药物，其心脏毒性有所降低。
J Med Chem. 1979 Jan;22(1):36-9. doi: 10.1021/jm00187a009.
6
Acute ultrastructural effects of the antitumor antibiotic carminomycin on nucleoli of rat tissues.抗肿瘤抗生素洋红霉素对大鼠组织核仁的急性超微结构效应
Cancer Res. 1979 Apr;39(4):1239-44.
7
Model systems for cardiotoxic effects of anthracyclines.
Antibiot Chemother (1971). 1978;23:255-70. doi: 10.1159/000401489.
8
Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents.
Biochem Pharmacol. 1979 Sep 1;28(17):2563-8. doi: 10.1016/0006-2952(79)90027-3.
9
NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.NADPH细胞色素P-450还原酶将醌类抗癌剂激活为自由基。
Proc Natl Acad Sci U S A. 1979 Feb;76(2):954-7. doi: 10.1073/pnas.76.2.954.
10
Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin.阿霉素和柔红霉素的氧化还原循环产生自由基和脂质过氧化。
Biochem Biophys Res Commun. 1977 Jul 25;77(2):797-803. doi: 10.1016/s0006-291x(77)80048-x.