Baum D, Beck R, Kodama A, Brown B
Circulation. 1980 Dec;62(6):1145-51. doi: 10.1161/01.cir.62.6.1145.
Height, weight, total body fat, lean body mass, size of fat cells and total number of lipid-containing fat cells were compared in two groups of children, ages 2-6 years, with congenital heart disease. Twelve children who developed heart failure in infancy made up one group and 14 asymptomatic patients made up the other. No patient was cyanotic or had undergone surgical repair. Patients with heart failure were shorter and lighter than asymptomatic patients. Whereas both fat and lean tissues were less in the heart failure group, reduction in body fat was more important in producing underweight. Although there was no difference in the size of fat cells, the number of lipid-laden fat cells was diminished in the children who had early heart failure. Thus hypocellularity of fat cells appeared to be the major determinant of diminished body fat with heart failure. Because shortness and decreased lean tissue were associated with these adipose tissue abnormalities, it is likely that widespread changes are caused by early heart failure. As previously reported with hypoxemia, the early development of heart failure seems to produce tissue changes that handicap growth.
对两组2至6岁患有先天性心脏病的儿童的身高、体重、全身脂肪、瘦体重、脂肪细胞大小和含脂质脂肪细胞总数进行了比较。一组由12名婴儿期出现心力衰竭的儿童组成，另一组由14名无症状患者组成。没有患者出现发绀或接受过手术修复。心力衰竭患者比无症状患者更矮、更轻。虽然心力衰竭组的脂肪组织和瘦组织都较少，但身体脂肪减少对体重过轻的影响更大。虽然脂肪细胞大小没有差异，但早期出现心力衰竭的儿童中充满脂质的脂肪细胞数量减少。因此，脂肪细胞的细胞减少似乎是心力衰竭时身体脂肪减少的主要决定因素。由于身材矮小和瘦组织减少与这些脂肪组织异常有关，早期心力衰竭很可能导致广泛的变化。正如先前关于低氧血症的报道，心力衰竭的早期发展似乎会产生阻碍生长的组织变化。
