Reiffel J A, Gang E, Gliklich J, Weiss M B, Davis J C, Patton J N, Bigger J T
Circulation. 1980 Dec;62(6):1324-34. doi: 10.1161/01.cir.62.6.1324.
To improve methods for evaluating human sinus node function (SNF), we developed a transvenous electrode catheter technique for direct recording of sinus node electrograms in adults. Sinus node electrograms (SNE) characterized by low-frequency, anatomically localized pre-P-wave potentials were obtained in 19 of 23 patients. The SNE configuration was similar to that previously found for endocardial SNE recordings in in vitro atrial preparations, in open-chest dogs and during human open heart surgery. In 16 patients with normal SNF, directly recorded sinoatrial conduction times (SACTs) were 46-116 msec. In three patients with sick sinus syndrome, SACT was 110-126 msec. In 15 of the 19 patients, SACT was estimated by the atrial premature stimulus technique and was compared with the directly measured SACT. When atrial premature depolarizations produced no sinus node depression, the mean differences between the direct and estimated SACT was 1.8 +/- 5.6 msec.
为改进评估人体窦房结功能（SNF）的方法，我们开发了一种经静脉电极导管技术，用于直接记录成人窦房结电图。在23例患者中的19例获得了以低频、解剖学定位的P波前电位为特征的窦房结电图（SNE）。SNE的形态与先前在体外心房标本、开胸犬和人类心脏直视手术中的心内膜SNE记录相似。在16例窦房结功能正常的患者中，直接记录的窦房传导时间（SACT）为46 - 116毫秒。在3例病态窦房结综合征患者中，SACT为110 - 126毫秒。在19例患者中的15例，通过心房早搏刺激技术估算SACT，并与直接测量的SACT进行比较。当心房早搏去极化未引起窦房结抑制时，直接测量与估算的SACT之间的平均差值为1.8±5.6毫秒。
