Penney L L, Klenke W J
Clin Chem. 1980 Dec;26(13):1800-3.
We determined unconjugated and total estriol concentrations in serum during the third trimester in 34 normal gestations. Data were obtained weekly for 13 women for as long as nine weeks; 21 others were studied daily for up to 15 days. No correlation between birth weight and either estriol fraction was demonstrated. Between-patient variability was less for unconjugated estriol and was similar for weekly and daily data. Within-patient variability was also less for unconjugated estriol and, as expected, was less for daily than for weekly data. The CV for daily samples, within patient, averaged 13.0% for unconjugated estriol and 20.3% for total estriol. Our data support the daily determination of unconjugated estriol in serum, evaluated for percent changes from single or mean preceding values, as the preferred method of monitoring estriol during pregnancy.
我们测定了34例正常妊娠晚期血清中未结合雌三醇和总雌三醇的浓度。13名女性每周采集数据，长达9周；另外21名女性每天进行研究，最长达15天。未发现出生体重与任何一种雌三醇组分之间存在相关性。未结合雌三醇的患者间变异性较小，每周和每日数据的变异性相似。未结合雌三醇的患者内变异性也较小，并且正如预期的那样，每日数据的变异性小于每周数据。患者体内每日样本的未结合雌三醇变异系数平均为13.0%，总雌三醇为20.3%。我们的数据支持每日测定血清中未结合雌三醇，并根据前一个单一值或均值的百分比变化进行评估，这是孕期监测雌三醇的首选方法。
