Penney L L
J Reprod Med. 1980 Nov;25(5):259-62.
The serum unconjugated estriol, as a percent of total estriol, has been determined in third-trimester pregnancies studied longitudinally. The unconjugated fraction in any specific sample ranged from 4.1% to 21.6% of the total. The mean percent unconjugated estriol in 34 patients sampled 7 to 15 times each between 32 and 40 weeks of gestation ranged from 5.3% to 13.6%. Higher serum total estriol concentration correlates with a lower percent of unconjugated. The mean percent unconjugated decreases during the last eight weeks of gestation from 11.4% to 8.4%, with a calculated regression line of Y = 23.323--0.368X. Thus, the concentration of serum unconjugated estriol is relatively more constant. The majority of patients demonstrate a narrow range of percent serum unconjugated estriol. These circumstances, combined with ease of assay, support the use of serum unconjugated estriol in pregnancy estriol monitoring.
对妊娠晚期孕妇进行纵向研究，测定了血清中未结合雌三醇占总雌三醇的百分比。任何特定样本中未结合部分占总量的4.1%至21.6%。在妊娠32至40周期间，对34名患者进行了7至15次采样，未结合雌三醇的平均百分比在5.3%至13.6%之间。血清总雌三醇浓度越高，未结合部分的百分比越低。在妊娠的最后八周，未结合雌三醇的平均百分比从11.4%降至8.4%，计算出的回归线为Y = 23.323 - 0.368X。因此，血清未结合雌三醇的浓度相对更稳定。大多数患者血清未结合雌三醇的百分比范围较窄。这些情况，再加上检测简便，支持将血清未结合雌三醇用于孕期雌三醇监测。
