Sakakini J, Buster J E, Killam A P
Am J Obstet Gynecol. 1977 Mar 1;127(5):452-4. doi: 10.1016/0002-9378(77)90433-1.
The purpose of this study was to further validate a preliminary report concerning the clinical usefulness of serum unconjugated estriols as a marker of gestational age. Serial estriol values from 50 women with uncertain dates were plotted on semilogarithmic graphs and the gestational age predicted from the timing of the abrupt surge in estriol values which normally occurs between 35 and 36 weeks. The gestational age at birth, as determined by careful neonatal examination, agreed with the age predicted by the estriol surge within +/- 1 week.
本研究的目的是进一步验证一份关于血清未结合雌三醇作为孕周标志物临床实用性的初步报告。将50名孕周日期不确定的女性的系列雌三醇值绘制在半对数图上，并根据通常在35至36周之间出现的雌三醇值突然激增的时间来预测孕周。通过仔细的新生儿检查确定的出生时孕周与根据雌三醇激增预测的孕周在正负1周内相符。
