普萘洛尔撤药对正常及甲状腺功能亢进受试者甲状腺激素的影响。

The effect of propranolol withdrawal on thyroid hormones in normal and hyperthyroid subjects.

作者信息

Ross P J, Jones M K, John R

出版信息

Clin Endocrinol (Oxf). 1980 Jul;13(1):27-31. doi: 10.1111/j.1365-2265.1980.tb01019.x.

DOI:10.1111/j.1365-2265.1980.tb01019.x

Abstract

Blood thyroid hormone levels were measured during, and for 6 days after, treatment with propranolol (160 mg/day, 4-8 weeks) in five hyperthyroid patients and six normal volunteers. In hyperthyroid patients triiodothyronine (T3) and free triiodothyronine index (FT3I) rose to peak levels 60 h after propranolol withdrawal without significant change in thyroxine (T4) or Thyopac-3 test. In normal subjects no significant change in thyroid hormone levels was seen during propranolol treatment or withdrawal. The rise in T3 and FT3I coincides with, and may contribute to, the rebound increase in adrenergic activity after propranolol withdrawal in hyperthyroidism.

摘要

对5例甲状腺功能亢进患者和6名正常志愿者在使用普萘洛尔（160毫克/天，4 - 8周）治疗期间及治疗后6天测量了血液甲状腺激素水平。在甲状腺功能亢进患者中，停用普萘洛尔60小时后，三碘甲状腺原氨酸（T3）和游离三碘甲状腺原氨酸指数（FT3I）升至峰值水平，而甲状腺素（T4）或Thyopac - 3试验无显著变化。在正常受试者中，普萘洛尔治疗或停药期间甲状腺激素水平未见显著变化。甲状腺功能亢进患者停用普萘洛尔后T3和FT3I的升高与肾上腺素能活性的反弹性增加同时出现，且可能促成这种增加。