Andersen A N, Hertz J, Kjer J J, Eskildsen P C, Larsen P S, Svenstrup B, Nielsen J, Arends J
Clin Endocrinol (Oxf). 1980 Aug;13(2):151-5. doi: 10.1111/j.1365-2265.1980.tb01036.x.
Twenty-seven healthy females referred for legal abortion between the sixth and ninth week of pregnancy were treated for 1 week with either bromocriptine, metoclopramide or placebo. Serum prolactin was significantly (P < 0.01) elevated by metoclopramide and suppressed by bromocriptine. Despite a more than tenfold difference in circulating prolactin levels among these two groups, no significant difference was found in serum levels of progesterone, oestradiol, human chorionic gonadotrophin (hCG) human placental lactogen (hPL) or pregnancy specific B1-glycoprotein (SP1). These data suggest that circulating levels of prolactin below 150 ng/ml are without effect on either luteal or placental hormone secretion during early human pregnancy.
27名在妊娠第6至9周前来接受合法堕胎的健康女性，分别接受了为期1周的溴隐亭、甲氧氯普胺或安慰剂治疗。甲氧氯普胺可使血清催乳素显著升高（P < 0.01），而溴隐亭则可使其降低。尽管两组之间循环催乳素水平存在十多倍的差异，但在孕酮、雌二醇、人绒毛膜促性腺激素（hCG）、人胎盘催乳素（hPL）或妊娠特异性β1-糖蛋白（SP1）的血清水平上未发现显著差异。这些数据表明，在人类妊娠早期，低于150 ng/ml的循环催乳素水平对黄体或胎盘激素分泌均无影响。
