Perucca E, Bittencourt P, Richens A
Clin Pharmacokinet. 1980 Nov-Dec;5(6):576-82. doi: 10.2165/00003088-198005060-00006.
The effect of progressive dose increments on the steady-state serum concentration of carbamazepine has been investigated prospectively in 20 adult institutionalised epileptic patients receiving long term therapy with the drug. In all but 1 subject, a strong positive correlation between the serum carbamazepine concentration and the prescribed daily dose was found. The relationship appeared to be linear over the dosage range examined (600 to 1400mg in most patients). In some patients, a trend was observed for the extrapolated regression lines to yield positive y-axis intercepts. The latter were significantly different from zero in 3 patients. Although these findings suggest that the relationship between serum carbamazepine concentration and dose may be curvilinear over the lower range of doses, further studies are required to clarify this point.
前瞻性地研究了递增剂量对20例接受卡马西平长期治疗的成年住院癫痫患者稳态血清浓度的影响。除1例患者外，其余患者血清卡马西平浓度与规定日剂量之间均呈强正相关。在所研究的剂量范围内（大多数患者为600至1400mg），这种关系似乎呈线性。在一些患者中，观察到外推回归线有产生正y轴截距的趋势。其中3例患者的y轴截距显著不同于零。尽管这些发现表明，在较低剂量范围内，血清卡马西平浓度与剂量之间的关系可能是曲线关系，但仍需要进一步研究来阐明这一点。
