水蛭素对断奶仔猪内毒素诱导的弥散性血管内凝血（DIC）的影响。
Influence of hirudin on endotoxin-induced disseminated intravascular coagulation (DIC) in weaned pigs.
作者信息
Nowak G, Markwardt F
出版信息
Exp Pathol (Jena). 1980;18(7-8):438-43. doi: 10.1016/s0014-4908(80)80045-7.
PMID:7439313
Abstract
In weaned pigs endotoxin infusion caused pathological changes in the clotting system typical of consumption coagulopathy and DIC resulting in circulatory disturbances. Infusion of the specific thrombin inhibitor hirudin prevented the endotoxin-induced disorders such as haematological changes, microthrombosis in various organs and the increase in right ventricular pressure and in respiratory rate.
摘要
在断奶仔猪中，内毒素输注导致了消耗性凝血病和弥散性血管内凝血典型的凝血系统病理变化，进而引起循环系统紊乱。输注特异性凝血酶抑制剂水蛭素可预防内毒素诱导的紊乱，如血液学变化、各器官微血栓形成以及右心室压力和呼吸频率增加。
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