Medvedev B A, Mashkovskiĭ M D
Farmakol Toksikol. 1980 Jul-Aug;43(4):374-6.
It has been shown in experiments on unanesthesized rats with normal arterial blood pressure that the antidepressants azaphen, pyrazidol and inkasan as well as imipramine and amitryptyline reduce the hypotensive effect of clofelin. With the dosage build-up the antidepressants themselves start to exert the hypotensive effect. However, the antagonism to clofelin in relation to the arterial blood pressure is maintained. It is suggested that such an effect is consequent on the impairment of noradrenaline neuronal uptake induced by the antidepressants.
在对动脉血压正常的未麻醉大鼠进行的实验中发现，抗抑郁药阿扎芬、吡唑醇、因卡山以及丙咪嗪和阿米替林会降低可乐宁的降压作用。随着抗抑郁药剂量的增加，它们自身开始产生降压作用。然而，在动脉血压方面对可乐宁的拮抗作用依然存在。据推测，这种效应是由抗抑郁药引起的去甲肾上腺素神经元摄取受损所致。
