Smith L J, Mandy W J
J Immunol. 1978 Feb;120(2):624-9.
Group b allotypic determinants (b4, b5, b6, and b9) were detected on cottontail IgG by several assays including immunodiffusion, radioimmune binding, and inhibition of radiobinding. The results indicate that cottontail IgG possess some but not all of the subspecificities present on domestic rabbit IgG. Several cottontail rabbits exhibited three of the four possible allotypic markers. In these instances, however, only two populations of IgG molecules (i.e., phenogroups) could be detected, each bearing one, two, or three of the allotypes. Five separate and distinctive phenogroups were identified. The results suggest that the phenogroups represent products of multiple allelic genes for the constant region of cottontail rabbit kappa light chain.
通过免疫扩散、放射免疫结合和放射结合抑制等几种检测方法，在棉尾兔免疫球蛋白G（IgG）上检测到了B组同种异型决定簇（b4、b5、b6和b9）。结果表明，棉尾兔IgG具有家兔IgG上存在的部分而非全部亚特异性。几只棉尾兔表现出四种可能的同种异型标记中的三种。然而，在这些情况下，只能检测到两个IgG分子群体（即表型组），每个群体带有一种、两种或三种同种异型。鉴定出了五个独立且独特的表型组。结果表明，这些表型组代表了棉尾兔κ轻链恒定区多个等位基因的产物。
