Carmelli D
Genetics. 1980 Apr;94(4):1001-10. doi: 10.1093/genetics/94.4.1001.
Some generalized two-locus, major-gene models for traits exhibiting continuous expression are investigated. Conditions of gametic equilibria are stated as functions of the parameters characterizing the within phenotypic-genotypic distributions. Selection is stabilizing in favor of an optimum phenotype. It is established that an increase in the phenotypic variance facilitates stability of a central polymorphic state with tighter linkage. Also, with increased phenotypic variance in an additive two-locus selection model, a HARDY-WEINBERG type of equilibrium will be less central. The rate of convergence, in this case, is slowed down with an augmented environmental background.
研究了一些用于表现连续表达性状的广义双基因座主基因模型。配子平衡的条件表示为表征表型 - 基因型分布内部参数的函数。选择有利于最优表型,具有稳定作用。结果表明,表型方差的增加有利于具有更紧密连锁的中心多态状态的稳定性。此外,在加性双基因座选择模型中,随着表型方差增加,哈迪 - 温伯格平衡类型将不那么居中。在这种情况下,随着环境背景增加,收敛速度会减慢。