Comite F, Burrow G N, Jorgensen E C
Endocrinology. 1978 Jun;102(6):1670-4. doi: 10.1210/endo-102-6-1670.
Transfer of iodothyronine across the placenta in most species occurs only with difficulty. Recently, biologically active, nonhalogenated thyroid hormone analogs have been synthesized with properties which might favor placental transfer. To test this possibility, we compared the doses of T4, T3, and thyroid hormone analogs necessary to prevent propylthiouracil-induced goiter formation in rat fetuses. T4 and T3 prevented fetal goiter, but in doses that caused maternal hyperthyroidism; in contrast, the thyroid hormone analogs prevented fetal goiter in doses that were not thyrotoxic to the mother.
在大多数物种中，甲状腺原氨酸穿过胎盘的过程都很困难。最近，已合成出具有可能有利于胎盘转运特性的生物活性非卤化甲状腺激素类似物。为了验证这种可能性，我们比较了预防丙硫氧嘧啶诱导的大鼠胎儿甲状腺肿形成所需的T4、T3和甲状腺激素类似物的剂量。T4和T3可预防胎儿甲状腺肿，但所用剂量会导致母体甲状腺功能亢进；相比之下，甲状腺激素类似物在对母体无甲状腺毒性的剂量下即可预防胎儿甲状腺肿。
