Hofman A, Valkenburg H A, Vaandrager G J
J Epidemiol Community Health. 1980 Sep;34(3):179-81. doi: 10.1136/jech.34.3.179.
The relationship between sodium in drinking water and blood pressure was examined in 348 schoolchildren aged 7.7 to 11.7 years. They were born and living in three areas with different levels of sodium in the public drinking water. Sodium content of the water was either long-term low, long-term high, or short-term high. The three communities are closely comparable according to demographic characteristics. The mean values of systolic and diastolic blood pressure were higher in the high sodium areas. After adjustment for dissimilarities in distributions of weight, height, pulse rate, age, family history of hypertension, and time of blood pressure measurement, these differences remained constant, ranging from 1.8 to 4.0 mm Hg. Girls and boys showed essentially the same differences. Mean 24-hour sodium excretion was somewhat higher in the long-term low area; no differences were found in sodium-creatinine ratio. The regression coefficients between sodium excretion and blood pressure were not significant. The findings from this retrospective follow-up study support the hypothesis that sodium intake influences blood pressure. The association seems to be of a relatively short-term nature, as no differences in blood pressure levels were found between the long-term and short-term high areas.
对348名年龄在7.7至11.7岁的学童进行了饮用水中钠含量与血压之间关系的研究。他们出生并生活在三个公共饮用水钠含量不同的地区。水的钠含量要么长期处于低水平,要么长期处于高水平,要么短期处于高水平。根据人口统计学特征,这三个社区具有很强的可比性。高钠地区的收缩压和舒张压平均值更高。在对体重、身高、脉搏率、年龄、高血压家族史以及血压测量时间的分布差异进行调整后,这些差异依然存在,范围在1.8至4.0毫米汞柱之间。男孩和女孩表现出的差异基本相同。长期低钠地区的24小时平均钠排泄量略高;钠肌酐比值未发现差异。钠排泄量与血压之间的回归系数不显著。这项回顾性随访研究的结果支持钠摄入量会影响血压这一假设。这种关联似乎具有相对短期的性质,因为在长期高钠地区和短期高钠地区之间未发现血压水平存在差异。