Robertson J S
J Epidemiol Community Health. 1984 Sep;38(3):186-94. doi: 10.1136/jech.38.3.186.
Blood pressure measurements were made on children in their fourth year at secondary schools in parts of Scunthorpe Health District supplied with drinking water of varying sodium content. Of the 3131 children, 2740 were examined (1394 boys and 1346 girls). Boys had slightly higher systolic pressures and slightly lower diastolic pressures than the girls. There was no difference between the blood pressure distributions of children in areas supplied with water containing 105 mg/l sodium, 50 mg/l sodium, or less than 15 mg/l sodium. Small differences were found in the weights of children in these areas, and slightly more of the children in the area supplied with water containing more than 105 mg/l sodium had relatives who had been treated for hypertension. Standardisation for these factors did not show any relation between water salinity and either systolic or diastolic blood pressure. Studies of the urinary sodium, potassium, and the ratios of these to creatinine on a sample of 769 boys showed no correlation with assessments of usual sodium intake, but urinary sodium correlated well with salt and fluid intake at the meal immediately preceding examination. The relation between median blood pressure and urinary sodium concentration and lack of a clear relation with sodium creatinine ratio supports the hypothesis that it may be the ratio of salt to fluid intake rather than total dietary sodium that is relevant to the regulation of blood pressure.
在斯肯索普健康区部分地区的中学,对四年级的儿童进行了血压测量,这些地区供应的饮用水钠含量各不相同。在3131名儿童中,有2740名接受了检查(1394名男孩和1346名女孩)。男孩的收缩压略高于女孩,舒张压略低于女孩。在供应钠含量为105毫克/升、50毫克/升或低于15毫克/升水的地区,儿童的血压分布没有差异。在这些地区儿童的体重上发现了微小差异,并且在供应钠含量超过105毫克/升水的地区,有略多的儿童其亲属曾接受过高血压治疗。对这些因素进行标准化处理后,未发现水的盐度与收缩压或舒张压之间存在任何关联。对769名男孩的样本进行尿钠、钾及其与肌酐的比值研究表明,这些指标与通常钠摄入量的评估没有相关性,但尿钠与检查前一餐的盐和液体摄入量密切相关。血压中位数与尿钠浓度之间的关系以及与钠肌酐比值缺乏明确关系,支持了这样一种假设,即与血压调节相关的可能是盐与液体摄入量的比值,而非饮食中钠的总量。