Alderson M
J Epidemiol Community Health. 1980 Sep;34(3):182-5. doi: 10.1136/jech.34.3.182.
Although hair dyes have been shown to be highly mutagenic the literature on possible human cancer risk is confused. A variety of studies using different methods in different countries have provided a range of positive and negative findings. In the present study the observed and expected mortality among a sample of hairdressers identified in the 1961 census was examined and followed until 1978; attention was focused on five malignancies reported to have increased in male hairdressers in the other studies. The overall mortality and number of deaths from all neoplasms were lower than the 'expected' figures. No appreciable or significant excess was found for cancer of the oesophagus, larynx, lung, and bladder, or for leukaemia. The present report, based on the follow-up of nearly 2000 hairdressers for more than 15 years, provides no support for other work which has suggested that male hairdressers or barbers are at risk of certain cancers. These results provide only a limited probe into the influence of hair dyes; another part of the study involves follow-up of women hairdressers from the 1971 census, though it will be a number of years before enough deaths have accumulated to warrant analysis.
尽管染发剂已被证明具有高度致突变性,但关于其对人类可能致癌风险的文献却相互矛盾。不同国家采用不同方法进行的各种研究得出了一系列正反两方面的结果。在本研究中,对1961年人口普查中确定的一组美发师样本的观察死亡率和预期死亡率进行了调查,并跟踪至1978年;重点关注其他研究中报告男性美发师发病率有所增加的五种恶性肿瘤。所有肿瘤的总死亡率和死亡人数均低于“预期”数字。在食管癌、喉癌、肺癌、膀胱癌或白血病方面未发现明显或显著的超额发病情况。本报告基于对近2000名美发师长达15年以上的随访,不支持其他研究提出的男性美发师或理发师有患某些癌症风险的观点。这些结果只是对染发剂影响的有限探究;该研究的另一部分涉及对1971年人口普查中的女性美发师进行随访,不过要积累足够数量的死亡病例以进行分析还需要数年时间。