Kinlen L J, Harris R, Garrod A, Rodriguez K
Br Med J. 1977 Aug 6;2(6083):366-8. doi: 10.1136/bmj.2.6083.366.
The recent finding that many permanent and semipermanent hair dyes are strongly mutagenic in a laboratory test, together with the fact that single female hair-dressers had higher than expected death rates from breast-cancer in 1959-63, prompted a study into the use of hair dyes by patients with breast cancer and by matched controls. There was no difference between the patients and their controls in their use of hair dyes. There were also no significant differences between the two groups when the analysis was confinedto women who had used dyes over four years and over nine years before diagnosis. The only significant findings were a higher proportion of past or present smokers among women aged over 50 who used hair dyes and an association between hair dyes use and age at first pregnancy. Further epidemiological studies are clearly needed in view of the mutagenicity found in the Ames test, and the fact th & several human carcinogens are also mutagenic according to this test.
最近的一项研究发现，许多永久性和半永久性染发剂在实验室测试中具有很强的致突变性。此外，在1959年至1963年期间，单身女性美发师的乳腺癌死亡率高于预期。这些发现促使人们对乳腺癌患者和匹配的对照组使用染发剂的情况进行研究。结果发现，患者和对照组在使用染发剂方面没有差异。当分析仅限于在诊断前四年和九年以上使用过染发剂的女性时，两组之间也没有显著差异。唯一显著的发现是，50岁以上使用染发剂的女性中，过去或现在吸烟者的比例较高，以及使用染发剂与首次怀孕年龄之间存在关联。鉴于在艾姆斯试验中发现的致突变性，以及根据该试验许多人类致癌物也具有致突变性这一事实，显然需要进一步的流行病学研究。
