Kawakami M, Visessuvan S
Endokrinologie. 1978 Nov;72(3):265-75.
Serum prolactin concentration was studied in hemiovariectomized rats, hemiovariectomized rats bearing chronic estradiol benzoate (E2) implant either in the anterior (A-AHA) or in the middle (M-AHA) portion of the anterior hypothalamic area (AHA), and was also studied in ovariectomized AHA lesioned rats. Hemiovariectomy caused rise of serum porlactin which peaked at day 10 and thereafter declined to the basal level. E2 implanted in the M-AHA either unilaterally or bilaterally temporarily suppressed the serum porlactin rise induced by hemiovariectomy. Unilateral implant of E2 in the A-AHA elicited also a temporary but longer suppressive effect. Bilateral E2 implant in the A-AHA consistently suppressed serum prolactin of hemiovariectomized animals. Ovariectomized AHA lesioned rats responded to systemic E2 treatment with a slight increase of serum prolactin while the non-lesioned ovariectomized rats responded with a significant increase. The additional E2 treatment effectively enhanced serum prolactin elevation in AHA ablated animals. The results substantiated the involvement of the AHA in prolactin secretion as well as they disclosed the A-AHA as a dominant area while the M-AHA appears to be supplementary area for prolactin inhibition, provided that the areas were in response to E2 implantation.
研究了半卵巢切除大鼠、在前下丘脑区（AHA）前部（A - AHA）或中部（M - AHA）植入慢性苯甲酸雌二醇（E2）的半卵巢切除大鼠以及卵巢切除且AHA损伤大鼠的血清催乳素浓度。半卵巢切除术导致血清催乳素升高，在第10天达到峰值，此后降至基础水平。单侧或双侧在M - AHA植入E2可暂时抑制半卵巢切除术诱导的血清催乳素升高。在A - AHA单侧植入E2也产生暂时但更长时间的抑制作用。在A - AHA双侧植入E2持续抑制半卵巢切除动物的血清催乳素。卵巢切除且AHA损伤的大鼠对全身E2治疗的反应是血清催乳素略有增加，而未损伤的卵巢切除大鼠反应是血清催乳素显著增加。额外的E2治疗有效增强了AHA切除动物的血清催乳素升高。结果证实了AHA参与催乳素分泌，同时揭示了A - AHA是一个主导区域，而M - AHA似乎是催乳素抑制的补充区域，前提是这些区域对E2植入有反应。
