Gvatua N A, Kravtsov V L, Ivanova L K, Shkliar L V, Shumakov V A
Kardiologiia. 1980 Oct;20(10):19-24.
Forty-four patients with acute myocardial infarction were given 0.15 mg/kg propranolol (obsidan) by intravenous drip, after which 80--160 mg of the drug were given daily by mouth for 4--5 days. The extent of the ischemic damage and the dynamics of the infarction zone were judged according to the results of electrocardiotopogram recorded from 35 leads and serial tests for creatine phosphokinase activity in blood serum. The hemodynamic shifts occurring under the effect of the treatment were determined in the same patients. The results were compared with those in a control group (37 patients) identical in clinical and hemodynamic signs. It is established that obsidan given by the schedule proposed reduces significantly the electrocardiographic signs of ischemic damage to the myocardium (according to the ST segment) and the spread of the zone of necrosis in the first days of the follow-up. This is attended by deceleration of the cardiac rhythm and a decrease in systemic arterial pressure and cardiac output. The hemodynamic shifts occur within the ranges of admissible fluctuations and do not cause circulatory insufficiency as a rule.
