Sampson D A, Pitas R E, Jensen R G
Lipids. 1980 Oct;15(10):815-22. doi: 10.1007/BF02534371.
Male weanling rats were fed semipurified diets with and without essential fatty acid (EFA) and DDT (150 ppm) for 14 weeks to determine the effects of the pesticide on physiological and biochemical aspects of EFA deficiency (EFAD). DDT did not affect EFAD-induced reduction in growth rate of final body weight, nor did the pesticide affect EFAD-induced changes in feed efficiency or skin dermatitis. The pesticide did increase liver/body mass ratios, but did not interact with EFAD, which also increased this ratio. The pesticide produced complex changes in total fatty acid composition of liver and tail skin; liver levels of 18:0, 18:2 and 20:3 omega 9 were increased, whereas levels of 12:0, 14:0 and 16:0 were decreased. In both tissues, DDT interacted with EFA to increase 18:2 levels. DDT did not change the total fatty acid 20:3 omega 9/20:4 omega 6 ratio in either tissue. In this study, although DDT did not exacerbate the physiological aspects of EFAD, DDT-induced changes in fatty acid composition of liver and tail skin indicated that 150 ppm DDT in the diets did alter lipid metabolism of the rats in an unexplained manner.
将雄性断乳大鼠分别饲喂含和不含必需脂肪酸（EFA）以及含150 ppm滴滴涕（DDT）的半纯化日粮14周，以确定该农药对必需脂肪酸缺乏（EFAD）的生理和生化方面的影响。滴滴涕不影响EFAD引起的最终体重生长速率降低，该农药也不影响EFAD引起的饲料效率变化或皮肤炎。该农药确实增加了肝脏/体重比，但未与EFAD相互作用，EFAD也会增加此比例。该农药使肝脏和尾部皮肤的总脂肪酸组成发生了复杂变化；肝脏中18:0、18:2和20:3ω9的水平升高，而12:0、14:0和16:0的水平降低。在这两种组织中，滴滴涕与必需脂肪酸相互作用以增加18:2的水平。滴滴涕未改变任一组织中总脂肪酸20:3ω9/20:4ω6的比例。在本研究中，尽管滴滴涕未加剧EFAD的生理方面，但滴滴涕引起的肝脏和尾部皮肤脂肪酸组成变化表明，日粮中150 ppm的滴滴涕确实以一种无法解释的方式改变了大鼠的脂质代谢。
