Berdanier C D, de Dennis S K
J Toxicol Environ Health. 1977 Jan;2(3):651-6. doi: 10.1080/15287397709529466.
Two groups of 30 male weanling rats were maintained on a nutritionally adequate diet containing 45% carbohydrate, 16% fat, and 29% protein with or without 1 ppm added DDT. At 100 days of age the two groups were subjected to an oral glucose tolerance test. The groups were then subdivided and half of each group was forced to run 1/16 mi/30 min-day on a treadmill. At 190 days of age the glucose tolerance test was repeated. The animals were killed at 200 days of age, and the lipid content of the serum, liver, and carcass was determined. Serum insulin levels and the DDT levels in the adipose tissue reflected the DDT content of the diet, and no differences in these levels were demonstrated with the addition of the exercise treatment. DDT treatment resulted in lower serum and liver cholesterol and serum insulin levels in sedentary rats. Exercise lowered liver cholesterol and serum insulin in non-DDT-treated rats. When both treatments were imposed, serum insulin cholesterol levels rose. Significant DDT-exercise interaction effects were observed on the glucose tolerance, serum and liver cholesterol, and serum insulin levels.
两组各30只雄性断奶大鼠，分别喂食营养充足、碳水化合物含量为45%、脂肪含量为16%、蛋白质含量为29%的饲料，其中一组添加1 ppm的滴滴涕（DDT），另一组不添加。在100日龄时，两组大鼠都接受口服葡萄糖耐量试验。然后将每组再分成两半，每组中的一半大鼠被迫在跑步机上每天跑1/16英里/30分钟。在190日龄时重复进行葡萄糖耐量试验。在200日龄时处死动物，并测定血清、肝脏和胴体的脂质含量。血清胰岛素水平和脂肪组织中的滴滴涕水平反映了饮食中的滴滴涕含量，并且运动处理并未显示出这些水平存在差异。滴滴涕处理导致久坐不动的大鼠血清和肝脏胆固醇以及血清胰岛素水平降低。运动降低了未接受滴滴涕处理的大鼠的肝脏胆固醇和血清胰岛素水平。当同时进行两种处理时，血清胰岛素胆固醇水平升高。在葡萄糖耐量、血清和肝脏胆固醇以及血清胰岛素水平方面观察到了显著的滴滴涕 - 运动交互作用。
