源自α-羟基亚甲基酮的氮芥。
Nitrogen mustards derived from alpha-hydroxymethyleneketones.
作者信息
Mariani E, Tasca A, Bignardi G, Schenone P
出版信息
Farmaco Sci. 1978 Aug;33(8):612-7.
PMID:744257
Abstract
alpha-[Bis-(2-chloroethyl)]aminomethyleneketones were prepared starting from alpha-hydroxymethyleneketones and N-(2-chloroethyl)-2-chloroethanamine. Also 3-[2-(2-chloroethylthio)ethyl]aminomethylene-2-bornanone was synthesized from 2-(2-chloroethylthio)ethanamine and 3-hydroxymethylene-2-bornanone. This compound and 3-[bis-(2-chloroethyl]aminoemthylene-2-norbornanone were active against P388 lymphocytic leukemia in mice.
摘要
α-[双-(2-氯乙基)]氨亚甲基酮由α-羟亚甲基酮和N-(2-氯乙基)-2-氯乙胺制备而成。此外，3-[2-(2-氯乙硫基)乙基]氨亚甲基-2-冰片酮由2-(2-氯乙硫基)乙胺和3-羟亚甲基-2-冰片酮合成。该化合物和3-[双-(2-氯乙基)]氨亚甲基-2-降冰片酮对小鼠P388淋巴细胞白血病具有活性。
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