Evaldson G, Carlström G, Lagrelius A, Malmborg A S, Nord C E
Med Microbiol Immunol. 1980;168(4):283-97. doi: 10.1007/BF02121812.
From 30 consecutive cases of premature rupture of the membranes (PROM) and matched controls, specimens from urine, cervix, amniotic fluid, and placenta as well as neonatal nose and throat swabs were investigated bacteriologically and virologically. In addition virus serological investigation was done. Among the PROM cases the anaerobic cervical isolates outnumbered the aerobic ones, and the total number of aerobic as well as anaerobic isolates was less in the control group. The anaerobes B. fragilis and Strept. intermedius were isolated from the cervix, amniotic fluid, or placenta in 23% and 30% of the PROM patients, respectively. None of the controls harboured B. fragilis, while Strept. intermedius was isolated from 6.7% of the controls. Group B streptococci were recovered from the mother's cervix in 20% of the PROM patients and in 6.7% among the controls. Four cases of neonatal septicaemia were encountered, and another two cases were clinically suspected, but not microbiologically verified, contributing to a high perinatal mortality rate (17,6%). Of the PROM patients, 27% developed puerperal infection, while none of the control mothers had such complications. The significance of the anaerobic bacteria as well as group B streptococci for the maternal and neonatal outcome in cases of PROM is discussed, and a possible aetiological role of ascending infection in this complication of pregnancy is postulated.
对30例连续的胎膜早破（PROM）病例及其匹配的对照组，对尿液、宫颈、羊水、胎盘标本以及新生儿鼻喉拭子进行了细菌学和病毒学研究。此外，还进行了病毒血清学研究。在胎膜早破病例中，宫颈厌氧分离株数量超过需氧分离株，对照组中需氧和厌氧分离株的总数较少。脆弱拟杆菌和中间链球菌分别在23%和30%的胎膜早破患者的宫颈、羊水或胎盘中分离得到。对照组中无一例携带脆弱拟杆菌，而6.7%的对照组分离出中间链球菌。20%的胎膜早破患者的母亲宫颈中检出B族链球菌，对照组中为6.7%。发生了4例新生儿败血症，另有2例临床疑似但微生物学未确诊，导致围产期死亡率较高（17.6%）。胎膜早破患者中，27%发生产褥感染，而对照组母亲均无此类并发症。讨论了厌氧菌以及B族链球菌对胎膜早破病例中母婴结局的意义，并推测上行感染在这种妊娠并发症中的可能病因学作用。
