Evaldson G R, Larsson B, Jiborn H, Nord C E
Eur J Obstet Gynecol Reprod Biol. 1987 Jul;25(3):259-66. doi: 10.1016/0028-2243(87)90108-0.
Apart from solely mechanical explanations, premature rupture of the membranes (PROM) has been suggested to be caused by an ascending infection. In order to investigate the role of infection in the mechanism of PROM, pregnant ewes were experimentally inoculated endocervically with either Bacteroides fragilis, Streptococcus intermedius or group B streptococci. These microorganisms were previously reported to be implicated in PROM in humans. The present investigation concerns the possible effect of an experimentally induced ascending infection on the collagen content and fibrinolytic activity (FA) of the fetal membranes. No relationship was observed between an ascending infection during pregnancy and the collagen content content of the fetal membrane specimens. It was concluded that changes in the collagen content bear no etiological significance in the mechanism of premature membrane rupture irrespective of an ascending infection's being present or not. Concerning FA in only one case, experiencing a Strept. intermedius amnionitis, was an elevated FA value observed. This finding indicates that the involvement of FA in the process of membrane rupture following ascending infection during pregnancy cannot be ruled out.
除了单纯的机械性解释外，胎膜早破（PROM）被认为是由上行感染引起的。为了研究感染在胎膜早破机制中的作用，对怀孕母羊进行宫颈内实验性接种脆弱拟杆菌、中间型链球菌或B族链球菌。这些微生物此前有报道称与人类的胎膜早破有关。本研究关注实验性诱导的上行感染对胎膜胶原含量和纤溶活性（FA）的可能影响。在孕期的上行感染与胎膜标本的胶原含量之间未观察到相关性。得出的结论是，无论是否存在上行感染，胶原含量的变化在胎膜过早破裂机制中均无病因学意义。关于纤溶活性，仅在一例发生中间型链球菌羊膜炎的病例中观察到纤溶活性值升高。这一发现表明，不能排除纤溶活性在孕期上行感染后胎膜破裂过程中的参与。
