Pizzuto J, Aviles A, Conte G, Morales M, Ambriz R, Butron L
Med Pediatr Oncol. 1980;8(1):41-6. doi: 10.1002/mpo.2950080107.
Histiocytic medullary reticulosis (HMR) is a rare, malignant disorder with unsatisfactory response to various chemotherapeutic agents that have been used up to the present time. The purpose of this communication is to describe the first patient with this disease in whom an immediate, complete remission was obtained using only adriamycin. Four months after institution of this treatment, a staging laparotomy and splenectomy revealed residual disease in the spleen only. Adriamycin was continued as the sole agent, to the full calculated dose, followed by maintenance therapy consisting of cyclophosphamide. The patient continues to be in complete remission 35 months after diagnosis was established.
组织细胞性髓性网状细胞增生症（HMR）是一种罕见的恶性疾病，对目前使用的各种化疗药物反应不佳。本文的目的是描述首例仅使用阿霉素就立即获得完全缓解的该疾病患者。在开始这种治疗四个月后，分期剖腹探查术和脾切除术显示仅脾脏有残留病灶。继续将阿霉素作为唯一药物，给予全部计算剂量，随后进行环磷酰胺维持治疗。自确诊以来35个月，该患者持续处于完全缓解状态。
