Cabanillas F, Rodriquez V, Valdivieso M, Butler J J, Burke J S
Med Pediatr Oncol. 1978;4(1):29-34. doi: 10.1002/mpo.2950040106.
Adult malignant histiocytosis, also known as histiocytic medullary reticulosis, has been, in the past, considered a very aggressive disorder usually resistant to chemotherapy. Management in the past has included either single agent therapy or splenectomy. Recently, several cases have been reported that have responded favorably to combination chemotherapy. This paper reports on our experience with combination chemotherapy for this disorder. Of three patients treated, all three responded with a complete remission and two remain alive and free of disease at the present time. The outlook for patients with this diagnosis appears to be changing favorably with the advent of new treatment regimens.
成人恶性组织细胞增多症，过去也被称为组织细胞性髓性网状细胞增多症，曾被认为是一种极具侵袭性且通常对化疗耐药的疾病。过去的治疗方法包括单药治疗或脾切除术。最近，有几例报告显示联合化疗取得了良好疗效。本文报告了我们在这种疾病联合化疗方面的经验。在接受治疗的3例患者中，全部3例均完全缓解，目前有2例存活且无疾病复发。随着新治疗方案的出现，这种诊断的患者预后似乎正朝着有利的方向转变。
