Weintraub H
Nucleic Acids Res. 1980 Oct 24;8(20):4745-53. doi: 10.1093/nar/8.20.4745.
The packaging of DNA into chromatin probably places certain restrictions on how specific DNA sequences can be recognized by DNA sequence specific recognition proteins (SRP). Several unique features of this type of interaction are discussed. Specifically, as a consequence of the coiling of the DNA about a histone core, it is proposed that DNA recognition sites will be compound and that each element of the compound recognition site will be about 10 - 20 b.p. in length and distributed at approximately 80 b.p. intervals--the periodicity of the DNA wrapping around the nucleosome.
DNA包装成染色质可能对特定DNA序列特异性识别蛋白(SRP)识别特定DNA序列的方式施加了某些限制。本文讨论了这种相互作用类型的几个独特特征。具体而言,由于DNA围绕组蛋白核心盘绕,有人提出DNA识别位点将是复合的,并且复合识别位点的每个元件长度约为10 - 20个碱基对,且以大约80个碱基对的间隔分布——这是DNA围绕核小体缠绕的周期性。