小剂量甘草诱发的严重低钾血症伴麻痹
Severe hypokalaemia with paralysis induced by small doses of liquorice.
作者信息
Cumming A M, Boddy K, Brown J J, Fraser R, Lever A F, Padfield P L, Robertson J I
出版信息
Postgrad Med J. 1980 Jul;56(657):526-9. doi: 10.1136/pgmj.56.657.526.
Abstract
A patient, who presented with a flaccid quadriplegia due to profound hypokalaemia, is described. Hypokalaemia and myoglobinuria were caused by the ingestion of small amounts of liquorice contained in a laxative preparation. Subsequent controlled administration of small amounts of this preparation induced marked hypokalaemia. This was associated with sodium retention and potassium loss confirming a mineralocorticoid-like action. The sodium retention was associated with suppression of plasma levels of renin and aldosterone.
摘要
本文描述了一名因严重低钾血症而出现弛缓性四肢瘫痪的患者。低钾血症和肌红蛋白尿是由服用一种缓泻制剂中含有的少量甘草引起的。随后对该制剂进行小剂量的控制性给药诱发了明显的低钾血症。这与钠潴留和钾丢失相关，证实了类似盐皮质激素的作用。钠潴留与血浆肾素和醛固酮水平的抑制有关。
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本文引用的文献
1
Body Composition: Studies in the Human Being by the Dilution Principle.
Science. 1952 Apr 25;115(2991):447-54. doi: 10.1126/science.115.2991.447.
2
Estimation of total body sodium by isotopic dilution. II. Studies on infants and children: an example of a constant differential growth ratio.
J Clin Invest. 1951 Jun;30(6):566-74. doi: 10.1172/JCI102473.
3
A liquorice extract with deoxycortone-like action.
Lancet. 1950 Sep 23;2(6630):381-6. doi: 10.1016/s0140-6736(50)91341-9.
4
Inhibition of the "mineralocorticoid" activity of licorice by spironolactone.
J Clin Endocrinol Metab. 1962 Nov;22:1156-9. doi: 10.1210/jcem-22-11-1156.
5
6
The measurement of exchangeable sodium in man using the isotope 24Na.
Clin Sci. 1953 May;12(2):97-111.
7
Hypokalaemia, flaccid quadruparesis, and myoglobinuria with carbenoxolone (biogastrone).
Br Med J. 1966 Jun 25;1(5503):1581-2. doi: 10.1136/bmj.1.5503.1581.
8
Hypokalemic myopathy with myoglobinuria associated with licorice ingestion.
N Engl J Med. 1966 Mar 17;274(11):602-6. doi: 10.1056/NEJM196603172741104.
9
Muscle paresis and hypokalemia after treatment with duogastrone.
Br Med J. 1969 Jun 14;2(5658):674. doi: 10.1136/bmj.2.5658.674.
10
Licorice-induced pseudoaldosteronism. Hypertension, hypokalemia, aldosteronopenia, and suppressed plasma renin activity.
JAMA. 1968 Aug 12;205(7):492-6. doi: 10.1001/jama.205.7.492.
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