Epstein M T, Espiner E A, Donald R A, Hughes H
Br Med J. 1977 Feb 19;1(6059):488-90. doi: 10.1136/bmj.1.6059.488.
The effect of confectionery liquorice on electrolyte status and the renin-angiotensin-aldosterone (RAA) axis was studied in 14 healthy volunteers. They ate liquorice in daily doses of 100 g or 200 g (equivalent to 0-7-1-4 g glycyrrhizinic acid) for one to four weeks. Plasma potassium concentrations fell by over 0-3 mmol/l in 11 people, including four who had to be withdrawn from the study because of hypokalaemia. One or more values of the RAA axis, especially plasma renin activity and urinary aldosterone concentrations, were considerably depressed in all subjects. These results show that potentially serious metabolic effects may occur in some people who eat modest amounts of liquorice daily for less than a week.
对14名健康志愿者研究了糖果甘草对电解质状态及肾素 - 血管紧张素 - 醛固酮（RAA）轴的影响。他们连续一至四周每日食用100克或200克甘草（相当于0.7 - 1.4克甘草次酸）。11人的血浆钾浓度下降超过0.3 mmol/L，其中4人因低钾血症不得不退出研究。所有受试者的RAA轴的一项或多项指标，尤其是血浆肾素活性和尿醛固酮浓度，均显著降低。这些结果表明，一些人每日食用适量甘草不到一周就可能出现潜在的严重代谢影响。
