Song C W, Kang M S, Rhee J G, Levitt S H
Radiology. 1980 Dec;137(3):795-803. doi: 10.1148/radiology.137.3.7444064.
Blood flow in rat skin and muscle increased three- to fourfold during heating at 43 degrees C for one hour, while that in Walker tumors did not change significantly; however, blood flow in the tumors decreased a few hours after heating at 45 degrees C. The temperature of Walker tumors was significantly higher than in the muscle during heating, probably due to inefficient heat dissipation caused by the sluggish blood flow. Severe vascular occlusion occurred in SCK tumors in mice after heating at 41.5-45.0 degrees C. Upon heating, the pH in the tumors significantly decreased, while that in the muscle increased. The clonogenic cell number continuously decreased when SCK tumors were left in situ after hyperthermia. The vascular occlusion and increase in acidity may account for the progressive death of tumor cells after heating.
在43摄氏度加热1小时期间，大鼠皮肤和肌肉中的血流量增加了三到四倍，而沃克肿瘤中的血流量没有显著变化；然而，在45摄氏度加热后几小时，肿瘤中的血流量减少。加热期间，沃克肿瘤的温度明显高于肌肉，这可能是由于血流缓慢导致散热效率低下所致。在41.5 - 45.0摄氏度加热后，小鼠的SCK肿瘤发生严重血管闭塞。加热时，肿瘤中的pH值显著降低，而肌肉中的pH值升高。热疗后将SCK肿瘤留在原位时，克隆形成细胞数量持续减少。血管闭塞和酸度增加可能是加热后肿瘤细胞逐渐死亡的原因。
