Rozencweig M, Abele R, Piccart M, Von Hoff D D, Muggia F M
Recent Results Cancer Res. 1980;74:72-7. doi: 10.1007/978-3-642-81488-4_10.
N-(Phosphonoacetyl)-L-aspartate (PALA) is a synthetic antimetabolite exhibiting striking oncolytic properties against a wide variety of experimental solid tumors. The clinical dose-limiting factor is mucocutaneous toxicity which is reversible and dose-related. Delineation of the single-agent activity of PALA in human cancer must still await results of recently activated trials.
