苏格兰东北部的冠心病：一项关于血清脂蛋白及其他变量的遗传与环境变异研究

Coronary heart disease in North-East Scotland a study of genetic and environmental variation in serum lipoproteins and other variables.

Robertson F W, Cumming A M, Douglas A S, Smith E B, Kenmure A C

Scott Med J. 1980 Jul;25(3):212-21. doi: 10.1177/003693308002500306.

Abstract

Serum lipoprotein concentrations and other variables such as relative weight, skinfold thickness, blood pressure, serum glucose, uric acid, fibrinogen smoking habits, etc. have been recorded on about 700 persons, including about 200 survivors of myocardial infarction under age 50 years, 250 of their relatives and 250 unrelated controls. 2. Elevated levels of VLDL and LDL are several times more frequent in survivors of infarction than in controls. 3. Cigarette smoking is associated with 20 to 30 per cent increase in VLDL. 4. Relative weight and skinfold thickness together account for a quarter of the variance of VLDL in men, 9 per cent in women. 5. LDL and HDL are uncorrelated; there is a low, consistently negative correlation between HDL and VLDL and IDL. 6. Parent-offspring regression and sib correlations indicate high, intermediate and low heritability for respectively HDL, LDL and VLDL. First degree relatives of survivors of infarction have levels of VLDL, IDL and LDL but not HDL.

摘要

已记录了约700人的血清脂蛋白浓度以及其他变量，如相对体重、皮褶厚度、血压、血清葡萄糖、尿酸、纤维蛋白原、吸烟习惯等，其中包括约200名年龄在50岁以下的心肌梗死幸存者、250名他们的亲属以及250名无血缘关系的对照者。2. 梗死幸存者中极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）水平升高的情况比对照组频繁几倍。3. 吸烟与VLDL升高20%至30%相关。4. 相对体重和皮褶厚度共同解释了男性VLDL变异的四分之一，女性的9%。5. LDL和高密度脂蛋白（HDL）不相关；HDL与VLDL和中间密度脂蛋白（IDL）之间存在低的、持续的负相关。6. 亲子回归分析和同胞相关性表明，HDL、LDL和VLDL的遗传率分别为高、中、低。梗死幸存者的一级亲属有VLDL、IDL和LDL水平升高，但HDL水平无变化。