Lees A W, Giuffre C, Burns P E, Hurlburt M E, Jenkins H J
Surg Gynecol Obstet. 1980 Dec;151(6):721-4.
A retrospective study of two methods of ovarian ablation as primary therapy for metastatic carcinoma of the breast was carried out using records from this cancer institute. Sixty-one radiation and 97 surgical ovarian ablations, performed from 1972 to 1977, were assessed. Rigid criteria were used to classify response. Over-all response was similar for the surgical and irradiation groups. Survival from the time of ovarian ablation was greater in both groups in those who responded positively than in those who did not. Factors other than estrogen receptor status can determine the response of patients with metastatic carcinoma of the breast to ovarian ablation. These include the disease-free interval, menopausal status, weight and the presence of skeletal or ovarian metastases. The results indicate that clinical determinates and not the efficiency of one method over the other should be the main criteria for choosing between ovarian ablation by irradiation or by oophorectomy.
利用该癌症研究所的记录，对两种卵巢去势方法作为乳腺癌转移癌的主要治疗方法进行了一项回顾性研究。对1972年至1977年期间进行的61例放疗卵巢去势和97例手术卵巢去势进行了评估。采用严格的标准对反应进行分类。手术组和放疗组的总体反应相似。两组中，卵巢去势后有阳性反应者的生存期均长于无阳性反应者。除雌激素受体状态外，其他因素也可决定乳腺癌转移癌患者对卵巢去势的反应。这些因素包括无病间期、绝经状态、体重以及骨骼或卵巢转移的存在情况。结果表明，临床决定因素而非一种方法相对于另一种方法的效率，应成为在放疗或卵巢切除术进行卵巢去势之间进行选择的主要标准。
