Wilkins T D, Walker C B, Nitzan D, Salyers A A
J Infect Dis. 1977 Mar;135 Suppl:S13-7. doi: 10.1093/infdis/135.supplement.s13.
Experimental anaerobic infections in mice are reviewed with a description of a model of pure Bacteroides fragilis infection. In this experimental situation, B. fragilis produces large subcutaneous abscesses in the groins of mice that can be diagnosed without autopsy. This infection was treated effectively with clindamycin in doses that produced levels of drug in blood similar to those attainable in humans.
本文综述了小鼠实验性厌氧感染，并描述了脆弱拟杆菌纯感染模型。在这种实验情况下，脆弱拟杆菌在小鼠腹股沟产生大的皮下脓肿，无需尸检即可诊断。用克林霉素有效治疗了这种感染，所用剂量在血液中产生的药物水平与人类可达到的水平相似。
