Rnr基因位于小鼠颌下腺中调控肾素的基因在1号染色体上的位置。
Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.
作者信息
Wilson C M, Erdös E G, Wilson J D, Taylor B A
出版信息
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5623-6. doi: 10.1073/pnas.75.11.5623.
Abstract
Renin activity (EC 3.4.99.19) was measured in submaxillary gland extracts from four sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity in androgen-treated female mice of all recombinant inbred strains resembled that of one or the other progenitor strains, as expected if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.
摘要
在四组重组近交系小鼠的颌下腺提取物中测量了肾素活性（EC 3.4.99.19）。发现介导颌下腺肾素对雄激素诱导敏感性的基因Rnr与1号染色体标记Dip-1之间的重组，在51个重组近交系中仅在1个中出现，这表明这两个基因在1号染色体上紧密连锁。正如预期的那样，如果是单个基因起作用，那么所有重组近交系经雄激素处理的雌性小鼠中的肾素活性类似于其中一个祖系的活性。有证据表明单个基因可对小鼠颌下腺中的肾素产生重大影响，这意味着单个基因差异可能解释其他物种中已知的肾素变化。
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