Wijeratne W V, Wells G A
Vet Rec. 1980 Nov 22;107(21):484-8. doi: 10.1136/vr.107.21.484.
A landrace boar with a previous history of siring progeny with cystic kidneys was bred to five unrelated large white sows. Thirty-eight of 61 progeny (62 per cent) were affected with renal cysts. This incidence does not differ significantly from that expected with autosomal dominant inheritance. Three of the dams and the boar were found at post mortem examination to have renal cysts. The number of cysts may be determined by polygenic inheritance. Study of the pathology of the cysts in one-day-old, 25- to 32-day-old and 370-day-old progeny indicated a complex pathogenesis including probable recruitment to the cyst population throughout the period studied. The syndrome studied did not resemble previously described polycystic syndromes of the pig nor was it closely comparable to any of the well described polycystic syndromes and renal cystic disorders of man.
一头曾繁育出患有肾囊肿后代的地方品种公猪与五头无亲缘关系的大白母猪进行配种。61头后代中有38头（62%）患有肾囊肿。这一发病率与常染色体显性遗传预期的发病率没有显著差异。在尸检时发现，其中三头母猪和这头公猪都有肾囊肿。囊肿的数量可能由多基因遗传决定。对1日龄、25至32日龄和370日龄后代的囊肿病理学研究表明，其发病机制复杂，包括在所研究的整个时期内可能有新的囊肿形成。所研究的综合征既不像先前描述的猪多囊综合征，也与人类任何已详细描述的多囊综合征和肾囊性疾病没有密切可比性。
