美国红十字会志愿献血人群中的肝炎相关标志物。I. 1975 - 1978年乙肝表面抗原（HBsAg）检测趋势

Hepatitis-associated markers in the American Red Cross volunteer blood donor population. I. Trends in HBsAg detection, 1975--1978.

作者信息

Bastiaans M J, Dodd R Y, Nath N, Pineda-Tamondong G, Sandler S G, Barker L F

出版信息

Vox Sang. 1980 Jul;39(1):1-8. doi: 10.1111/j.1423-0410.1980.tb01830.x.

DOI:10.1111/j.1423-0410.1980.tb01830.x

Abstract

From January 1975 to December 1978, 19,140,169 units of blood were collected by the American Red Cross at 57 regional locations. Each unit was tested for hepatitis B surface antigen (HBsAg) by a single commercial radioimmunoassay test system. A total of 15,954 donations were reported reactive, representing a rate of HBsAg reactivity of 0.83/1,000 units tested. The rate during 1975 was 0.94/1,000 units tested, decreasing to 0.71/1,000 units tested in 1978 (p < 0.005). The prevalence of HBsAg among first-time donors was 2.08/1,000 during 1977 and 1978, 2.7 times higher than that calculated for repeat donors (0.77/1,000 donors). Substantial geographic variation in the prevalence and rate of detection of HBsAg was observed.

摘要

1975年1月至1978年12月期间，美国红十字会在57个地区收集了19,140,169单位血液。每单位血液均通过单一商业放射免疫测定测试系统检测乙型肝炎表面抗原（HBsAg）。共有15,954份捐赠报告呈阳性反应，HBsAg反应率为每检测1,000单位0.83。1975年的反应率为每检测1,000单位0.94，到1978年降至每检测1,000单位0.71（p < 0.005）。1977年和1978年首次献血者中HBsAg的流行率为每1,000人2.08，比重复献血者的计算流行率（每1,000名献血者0.77）高2.7倍。观察到HBsAg流行率和检测率存在显著的地理差异。