Monnier L, Follea G, Mirouze J
Horm Metab Res. 1978 Nov;10(6):470-3. doi: 10.1055/s-0028-1093373.
Plasma Antithrombin III (At III), a natural inhibitor of coagulation, was determined using a single radial immunodiffusion technique. In 116 diabetics, plasma At III levels were significantly decreased (26.6 +/- 0.4 mg/100 ml) compared with those in 64 controls (31.0 +/- 0.3 mg/100 ml, P less than 0.001). An elevation of plasma fibrinogen degradation products in 42 per cent of our patients, and a positive linear relationship between platelet counts and At III levels ( r = 0.29, P less than 0.01), provided additional evidence for chronic disseminated intravascular clotting in diabetes mellitus. Diabetic retinal complications were more frequent in patient with low plasma At III levels (50.6 per cent of cases) than in those exhibiting At III concentrations within a normal range: 32.4 per cent of cases (X2 = 6.09, P less than 0.02). It is postulated that the low levels of At III encountered in diabetes result from excessive consumption, and that the deficiency may be responsible for the onset and/or aggravation of intravascular clotting. At III deficiency may therefore contribute to vascular degenerative complications, particularly those leading to diabetic retinopathy.
采用单向放射免疫扩散技术测定血浆抗凝血酶III（At III），它是一种天然的凝血抑制剂。116例糖尿病患者的血浆At III水平（26.6±0.4mg/100ml）与64例对照组（31.0±0.3mg/100ml，P＜0.001）相比显著降低。42%的患者血浆纤维蛋白原降解产物升高，且血小板计数与At III水平呈正线性关系（r = 0.29，P＜0.01），这些为糖尿病患者慢性弥散性血管内凝血提供了额外证据。血浆At III水平低的患者（50.6%的病例）糖尿病视网膜并发症比At III浓度在正常范围内的患者更常见：32.4%的病例（X2 = 6.09，P＜0.02）。据推测，糖尿病患者中At III水平低是由于过度消耗所致，这种缺乏可能是血管内凝血发生和/或加重的原因。因此，At III缺乏可能导致血管退行性并发症，尤其是导致糖尿病视网膜病变的并发症。
