Bosher S K
Acta Otolaryngol. 1980 May-Jun;89(5-6):407-18. doi: 10.3109/00016488009127156.
The endolymphatic changes produced by an intravenous injection of 60 mg kg-1 ethacrynic acid were followed for up to 120 min using conventional and ion-sensitive (Na+, K+ and pH) microelectrodes in the rat. They were found to be caused by three distinct effects upon the endolymph system. Initially, the drug completely inhibited the strial potential-producing and cation-transporting processes. Recovery began quickly and was rapid at first. Then its rate declined considerably, probably due to diminution in strial energy production of delayed onset and prolonged duration. Coincident with these actions upon active transport, there was a decrease in the overall cation permeability of the endolymph system. This followed a different time course and affected K+ much more than Na+. The findings also provided further information about the mechanisms responsible for the normal endolymphatic composition. Qualitatively similar results were obtained in a subsidiary study on guinea pigs.
在大鼠中，使用传统微电极和离子敏感（Na+、K+和pH）微电极，对静脉注射60 mg kg-1依他尼酸所产生的内淋巴变化进行了长达120分钟的跟踪研究。发现这些变化是由对内淋巴系统的三种不同作用引起的。最初，药物完全抑制了产生血管纹电位和阳离子转运的过程。恢复很快开始，起初速度很快。然后其速率大幅下降，可能是由于血管纹能量产生延迟且持续时间延长所致。与这些主动转运作用同时发生的是，内淋巴系统的整体阳离子通透性降低。这遵循不同的时间进程，对K+的影响远大于Na+。这些发现还提供了有关正常内淋巴成分形成机制的进一步信息。在对豚鼠的一项辅助研究中获得了定性相似的结果。
