内淋巴电位与内淋巴中钠和钾浓度的相互独立性。
The mutual independence of the endolymphatic potential and the concentrations of sodium and potassium in endolymph.
作者信息
Brusilow S W, Gordes E
出版信息
J Clin Invest. 1973 Oct;52(10):2517-21. doi: 10.1172/JCI107442.
Abstract
The relationship between the endolymphatic potential (EP) and the sodium and potassium concentration gradients between endolymph and interstitial fluid was studied both by measuring the EP at varying concentrations of sodium and potassium in endolymph and by measuring the effect of a depressed EP on the concentrations of these cations. Ethacrynic acid was used in dogs to change the concentration of sodium and potassium (meq/liter) in endolymph from 5.8 and 148 to 134 and 24.3, respectively. No change in the EP accompanied these alterations. In a second series of experiments the EP was reduced from + 72 mV to + 31 mV for a mean duration of 20 min. No change in the concentration of sodium and potassium in endolymph was found during the period of reduced EP. These data suggest that there is little relationship between the EP and the sodium and potassium concentrations in endolymph.
摘要
通过在内淋巴中不同钠钾浓度下测量内淋巴电位（EP）以及测量降低的EP对这些阳离子浓度的影响，研究了内淋巴电位与内淋巴和间质液之间钠钾浓度梯度的关系。在狗身上使用依他尼酸将内淋巴中钠和钾的浓度（毫当量/升）分别从5.8和148变为134和24.3。这些改变并未伴随EP的变化。在第二系列实验中，EP从+72 mV降至+31 mV，平均持续20分钟。在EP降低期间，未发现内淋巴中钠和钾浓度的变化。这些数据表明，EP与内淋巴中钠和钾的浓度之间几乎没有关系。
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