Kokkonen J
Acta Paediatr Scand. 1980 Jul;69(4):485-9. doi: 10.1111/j.1651-2227.1980.tb07119.x.
Circulating parietal cell antibodies (PCA) were fund in 8 (5.4%) out of 147 diabetic children screened. Both sexes were equally represented, but the titres were higher in the girls. No clear relationship between the presence of these antibodies and age or the duration of diabetes was observed. Gastric studies were performed on 8 children with PCA (group A) and 41 without PCA (group B). Both basal (BAO) and maximal acid output (MAO) were significantly (p < 0.05) lower and fasting serum gastrin elevated (p < 0.01) in group A as compared with the control group. Two patients were achlorhydric. In group B, 17 patients out of the 41 studied had hyposecretion and one achlorhydria. The result became most obvious in the group with a duration and diabetes over 10 years, where MAO was significantly diminished (p < 0.05). Gastric morphology revealed atrophic gastritis in 3 patients from seven biopsies in group A and one out five biopsies for severe hyposecretion in group B. Two other children in group A had superficial gastritis. Serum ferritin levels decreased along with the duration of diabetes. Those with gastric mucosa had the lowest values.
在筛查的147名糖尿病儿童中，有8名（5.4%）检测出循环壁细胞抗体（PCA）。男女比例相当，但女孩的抗体滴度更高。未观察到这些抗体的存在与年龄或糖尿病病程之间有明显关系。对8名有PCA的儿童（A组）和41名无PCA的儿童（B组）进行了胃部研究。与对照组相比，A组的基础胃酸分泌量（BAO）和最大胃酸分泌量（MAO）均显著降低（p<0.05），空腹血清胃泌素升高（p<0.01）。有两名患者无胃酸分泌。在B组的41名研究对象中，有17名胃酸分泌减少，1名无胃酸分泌。在病程超过10年的糖尿病患者组中，结果最为明显，其MAO显著降低（p<0.05）。胃部形态学检查显示，A组7次活检中有3例出现萎缩性胃炎，B组5次活检中有1例因严重胃酸分泌减少出现萎缩性胃炎。A组另外两名儿童患有浅表性胃炎。血清铁蛋白水平随糖尿病病程延长而降低。胃黏膜受损的患者血清铁蛋白水平最低。
