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红细胞转酮醇酶活性与婴儿猝死

Erythrocyte transketolase activity and sudden infant death.

作者信息

Peterson D R, Labbe R F, van Belle G, Chinn N M

出版信息

Am J Clin Nutr. 1981 Jan;34(1):65-7. doi: 10.1093/ajcn/34.1.65.

DOI:10.1093/ajcn/34.1.65
PMID:7446460
Abstract

Postmortem heart blood aspirates from 24 consecutive sudden infant deaths and 23 consecutive infant deaths from other causes yielded evidence of erythrocyte transketolase activity (ETKA) in every instance. ETKA measurements from cadaver specimens have not been previously reported. ETKA values did not correlate with the interval from death to sampling or with age at death. Activity coefficients from postmortem material corresponded closely to those from previous studies on living subjects which suggests that the method of Bayoumi and Rosalki yields valid measurements at least for 77 h postmortem. Statistical comparisons of the sudden infant deaths with non-sudden infant deaths revealed no significant differences. This investigation failed to disclose evidence in favor of the hypothesis, advanced by Read, that unsuspected thiamin deficiency may explain some cases of the sudden infant death syndrome.

摘要

对24例连续的婴儿猝死病例以及23例连续的因其他原因死亡的婴儿进行尸检时采集心脏血液样本,结果在每一病例中均发现了红细胞转酮醇酶活性(ETKA)的证据。此前尚无关于尸体标本ETKA测量值的报道。ETKA值与死亡至采样的时间间隔或死亡时的年龄均无相关性。尸检材料的活性系数与先前对活体受试者的研究结果密切对应,这表明Bayoumi和Rosalki的方法至少在死后77小时内能够得出有效的测量结果。对婴儿猝死病例与非婴儿猝死病例进行统计学比较,未发现显著差异。这项调查未能找到证据支持Read提出的假说,即未被怀疑的硫胺素缺乏可能解释某些婴儿猝死综合征病例。

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Erythrocyte transketolase activity and sudden infant death.红细胞转酮醇酶活性与婴儿猝死
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Erythrocyte transketolase activity and sudden infant death.红细胞转酮醇酶活性与婴儿猝死
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