Granroth G, Haapakoski J, Saxén L
Int J Epidemiol. 1978 Dec;7(4):301-8. doi: 10.1093/ije/7.4.301.
Based on the Finnish Register of Congenital Malformations a search was undertaken for associations between defects of the central nervous system [CNS] and various selected risk indicators. The study material consisted of 710 cases of CNS defects and their time-area matched pair controls. 259 cases of polydactyly and their controls were also compared with a view of demonstrating the possible biases introduced by the case-control method. The present report is a multivariate analysis of previously observed associations, and the linear logistic regression model was used for the elimination of confounding factors. Risk indicators remaining after the analysis were high maternal age, multipara with previous stillbirths and defective children, especially defects of the CNS. Maternal influenza, especially in combination with the intake of salicylates, was also associated with an increased risk.
基于芬兰先天性畸形登记册，对中枢神经系统（CNS）缺陷与各种选定风险指标之间的关联进行了研究。研究材料包括710例CNS缺陷病例及其按时间和地区匹配的对照。还比较了259例多指畸形病例及其对照，以证明病例对照法可能引入的偏差。本报告是对先前观察到的关联进行的多变量分析，并使用线性逻辑回归模型消除混杂因素。分析后剩余的风险指标包括孕妇高龄、有死产和缺陷儿童（尤其是CNS缺陷）的经产妇。孕妇感染流感，特别是与摄入水杨酸盐同时发生时，也与风险增加有关。
