Hemminki K, Mutanen P, Saloniemi I, Luoma K
J Epidemiol Community Health. 1981 Mar;35(1):5-10. doi: 10.1136/jech.35.1.5.
The Finnish Register of Congenital Malformations was used in a multivariate analysis to explore the associations between maternal occupation in industry and children born with central nervous system (CNS) or musculoskeletal or oral cleft malformations. Possible confounding factors were selected in preliminary screening of risk indicators for malformations. These factors included characteristics of the mother, the child, and the family; maternal illnesses; an maternal medication at the time of pregnancy. Tobacco smoking was a confounding factor for all type of malformations; number of children born to the mother, maternal age, malformations in the family, number of rooms occupied by the family, sex of the child, threatened abortion, and continuous medication of the mother during the first trimester confounded the association for certain type of malformations. After adjusting for confounding factors, maternal occupation in industrial trades significantly correlated with CNS, oral cleft, and musculoskeletal malformation in the offspring. Maternal occupation in industry and construction only was significantly associated with CNS malformations in the offspring but the associations with oral cleft and musculoskeletal malformations were not significant.
芬兰先天性畸形登记册被用于多变量分析，以探究母亲从事工业工作与患有中枢神经系统（CNS）、肌肉骨骼或腭裂畸形的儿童之间的关联。在对畸形风险指标进行初步筛选时选择了可能的混杂因素。这些因素包括母亲、孩子和家庭的特征；母亲的疾病；以及怀孕时母亲服用的药物。吸烟是所有类型畸形的混杂因素；母亲生育的子女数量、母亲年龄、家庭中的畸形情况、家庭居住房间数量、孩子性别、先兆流产以及母亲在孕早期持续用药对某些类型的畸形关联产生混杂影响。在对混杂因素进行调整后，母亲从事工业行业的工作与后代的中枢神经系统、腭裂和肌肉骨骼畸形显著相关。仅母亲从事工业和建筑业工作与后代的中枢神经系统畸形显著相关，但与腭裂和肌肉骨骼畸形的关联不显著。
