Granroth G
Early Hum Dev. 1978 Jul;2(2):147-62. doi: 10.1016/0378-3782(78)90007-5.
The matched pair system of the Finnish Register of Congenital Malformations was used to search for association between defects of the central nervous system (CNS), and maternal diseases and/or drug consumption during pregnancy. The study material consisted of 710 cases with CNS defects and their controls. Significant associations were found for the following conditions: influenza, threatened abortion, depressive state, toxemia of pregnancy, diabetic mothers, and for the consumption of the following drugs: salicylates, pyrazolones/anilines, euphoristic analgesics, sympathomimetics, barbiturates, and cough medicines. 259 cases with polydactyly and their controls were also compared, with a view to demonstrating what biases might be introduced by the case-control method. After utilizing the possibilities of this design for examining the above mentioned significant associations, the factors to be seriously considered were reduced to the following ones: influenza, depressive state, toxemia of pregnancy, diabetic mothers and cough medicines.
利用芬兰先天性畸形登记册的配对系统，来探寻中枢神经系统（CNS）缺陷与孕期母亲疾病和/或药物使用之间的关联。研究材料包括710例患有中枢神经系统缺陷的病例及其对照。发现以下情况存在显著关联：流感、先兆流产、抑郁状态、妊娠中毒症、糖尿病母亲，以及以下药物的使用：水杨酸盐、吡唑酮/苯胺、欣快性镇痛药、拟交感神经药、巴比妥类药物和止咳药。还比较了259例多指畸形病例及其对照，以证明病例对照法可能引入的偏差。在利用该设计来检验上述显著关联的可能性之后，需要认真考虑的因素减少到以下这些：流感、抑郁状态、妊娠中毒症、糖尿病母亲和止咳药。
