Cleary P E, Minckler D S, Ryan S J
Am J Ophthalmol. 1980 Dec;90(6):829-45. doi: 10.1016/s0002-9394(14)75198-0.
We studied the ultrastructural characteristics of an experimental model of traction retinal detachment secondary to a penetrating eye injury in the rhesus monkey. Cells with the characteristics of myofibroblasts were present in the intravitreal fibrous tissue and in epiretinal membranes. These cells were probably derived from many sources, and were capable of contraction through the mechanism of intracytoplasmic contractile proteins such as actin or myosin. The morphologic observations supported our hypothesis that traction retinal detachment is a cell-mediated event analogous to the processes of wound healing and wound contraction. The force of contraction is mediated by cell-to-cell and cell-to-vitreous connections and by glial bridges that connect epiretinal membranes to the retina. These ultrastructural studies, which provide insight into the pathogenesis of traction retinal detachment in the experimental animal model, may well have significant clinical relevance.
我们研究了恒河猴穿透性眼外伤继发牵引性视网膜脱离实验模型的超微结构特征。具有肌成纤维细胞特征的细胞存在于玻璃体内纤维组织和视网膜前膜中。这些细胞可能来源于多种途径，并且能够通过肌动蛋白或肌球蛋白等胞质收缩蛋白机制进行收缩。形态学观察支持了我们的假设，即牵引性视网膜脱离是一种细胞介导的事件，类似于伤口愈合和伤口收缩过程。收缩力由细胞间和细胞与玻璃体的连接以及连接视网膜前膜与视网膜的胶质桥介导。这些超微结构研究为实验动物模型中牵引性视网膜脱离的发病机制提供了深入了解，很可能具有重要的临床意义。
