Ussmann J H, Lazarides E, Ryan S J
Arch Ophthalmol. 1981 May;99(5):869-72. doi: 10.1001/archopht.1981.03930010869016.
In posterior-segment penetrating injuries, the role of cellular and extracellular structures for the development of fraction retinal detachment is a matter of controversy. With the use of immunofluorescence techniques, we studied the cellular components of intravitreal membranes, with particular attention to the presence of intracellular contractile proteins. Our results demonstrate increasing concentrations of intracellular actin filaments in 12- to 21-day-old membrane specimens at the time when traction retinal detachment is most likely to occur in the rabbit eye. The sequence of events reflects the same process that occurs in the wound-healing response throughout the body. The specialized anatomy of the eye, particularly the vitreoretinal relationship at the vitreous base, accounts for the disastrous consequence of fraction retinal detachment.
在后部节段性穿透伤中，细胞和细胞外结构在视网膜部分脱离发展过程中的作用存在争议。通过免疫荧光技术，我们研究了玻璃体内膜的细胞成分，特别关注细胞内收缩蛋白的存在。我们的结果表明，在12至21日龄的膜标本中，当兔眼最有可能发生牵拉性视网膜脱离时，细胞内肌动蛋白丝的浓度增加。事件序列反映了全身伤口愈合反应中发生的相同过程。眼睛的特殊解剖结构，特别是玻璃体基底部的玻璃体视网膜关系，导致了视网膜部分脱离的灾难性后果。
