Feldman E J, Grossman M I
Am J Physiol. 1980 Dec;239(6):G493-6. doi: 10.1152/ajpgi.1980.239.6.G493.
Using intragastric titration in dogs with gastric fistulas, dose-response studies were carried out with liver extract and with a mixture of amino acids that matched the free amino acids found in liver extract. All solutions were adjusted to pH 7.0 and osmolality to 290 mosmol x kg-1. Doses are expressed as the sum of the concentrations of all free amino acids. At each dose studied (free amino acid concentration: 2.8, 5.6, 11, 23, and 45 mM), acid secretion in response to the free amino acid mixture was not significantly different from that of liver extract. The peak response to both liver extract and the free amino acid mixture occurred with the 23-mM dose and represented about 60% of the maximal response to histamine. The serum concentrations of gastrin after liver extract and the amino acid mixture were not significantly different. It is concluded that in dogs with gastric fistula, gastric acid secretion and release of gastrin were not significantly different in response to liver extract and to a mixture of amino acids that simulated the free amino acid content of liver extract.
通过对患有胃瘘的狗进行胃内滴定，开展了肝脏提取物以及与肝脏提取物中游离氨基酸组成相匹配的氨基酸混合物的剂量-反应研究。所有溶液均调节至pH 7.0，渗透压调节至290 mosmol×kg⁻¹。剂量以所有游离氨基酸浓度之和表示。在所研究的每个剂量（游离氨基酸浓度：2.8、5.6、11、23和45 mM）下，游离氨基酸混合物引起的胃酸分泌与肝脏提取物引起的胃酸分泌无显著差异。肝脏提取物和游离氨基酸混合物的峰值反应均出现在23 mM剂量时，约占组胺最大反应的60%。肝脏提取物和氨基酸混合物给药后胃泌素的血清浓度无显著差异。得出的结论是，对于患有胃瘘的狗，肝脏提取物和模拟肝脏提取物游离氨基酸含量的氨基酸混合物在引起胃酸分泌和胃泌素释放方面无显著差异。
