Gough A, Rai V, Mariano E, Landor J H
Gut. 1980 Feb;21(2):91-3. doi: 10.1136/gut.21.2.91.
Gastric secretory dose-response studies, using an 8.5% mixed L-amino acid solution as the agonist, were carried out in three dogs with Heidenhain pouches and gastric fistulae. Secretory responses of the Heidenhain pouches were measured during two hour infusions of amino acids given at rates of 0, 0.05, 0.1, 0.2, 0.4, 0.8, and 1.6 g/kg/h and plasma amino nitrogen was measured before and during the infusion. Three separate studies at each dose level were made in each dog. The maximum secretory response occurred at the dose of 0.4 g/kg/h and amounted to approximately 20% of the maximal histamine response. Larger doses produced no additional increase in secretion or an actual decrease in secretory rate. It is concluded that the solution of amino acids used acts as a modest gastric agonist and that increases in plasma amino nitrogen such as may be observed after a protein meal are capable of eliciting a slight, but definite, gastric secretory response.
以8.5%的混合L - 氨基酸溶液作为激动剂，在三只装有海登海因小胃和胃瘘的狗身上进行了胃分泌剂量反应研究。在以0、0.05、0.1、0.2、0.4、0.8和1.6 g/kg/h的速率输注氨基酸的两小时期间，测量海登海因小胃的分泌反应，并在输注前和输注期间测量血浆氨基氮。每只狗在每个剂量水平进行三项独立研究。最大分泌反应出现在0.4 g/kg/h的剂量下，约为最大组胺反应的20%。更大的剂量不会使分泌进一步增加，或实际导致分泌速率下降。得出的结论是，所用的氨基酸溶液作为一种适度的胃激动剂，并且蛋白质餐后可能观察到的血浆氨基氮增加能够引发轻微但确定的胃分泌反应。
